Western Kentucky defeated Delaware 27-24 in Week 6, with the Hilltoppers covering the spread as the away team. The game featured six lead changes and remained competitive throughout, with Delaware's Nick Minicucci completing 314 passing yards but struggling in critical moments. Western Kentucky's Matthew Henry led all receivers with 99 yards.

The pivotal third quarter belonged to Western Kentucky's defense. Koron Hayward intercepted a Minicucci pass and returned it for a touchdown, while Elin Jones recovered a Minicucci fumble on another critical possession. These defensive plays swung momentum decisively in Western Kentucky's favor after Delaware had led 17-10 at halftime.

Western Kentucky scored 10 first-half points before erupting defensively in the third quarter and maintaining their advantage through the fourth. Delaware managed only 7 points in the second half despite Minicucci's strong passing performance. The contest finished under the 63-point over-under, with Western Kentucky's defense ultimately proving the difference in a game that saw multiple lead changes.